1. Outstanding Structural Characteristics and Excellent Reactivity
The molecule contains two aldehyde groups (-CHO) and one bromine atom (-Br) simultaneously, possessing both the electrophilicity of aldehyde groups and the leaving ability of bromine atoms. It can participate in various reactions such as substitution, condensation, and cyclization, providing flexible reaction sites for the construction of complex molecules.
The introduction of the bromine atom enhances the molecular polarity and reaction selectivity. Especially in the construction of nitrogen-containing heterocycles (e.g., pyrimidines, quinolines), it can precisely regulate the reaction pathway and reduce the formation of by-products.
2. Mature Synthesis Process with Dual Advantages in Purity and Yield
Existing synthesis methods (such as the tetramethoxypropane method and the 2-bromo-1,3-propanediol oxidation method) achieve stable yields (up to over 60%). Moreover, through process optimization like low-temperature control and catalyst selection, high-purity products (purity ≥97%) can be obtained, meeting the requirements of impurity-sensitive fields such as pharmaceutical and liquid crystal synthesis.
The raw materials (e.g., 1,1,3,3-tetramethoxypropane, bromine) are easily available, and the reaction conditions are conducive to industrial scale-up, making it suitable for mass production.
3. A Key Intermediate in Pharmaceutical and Material Synthesis
In the pharmaceutical field, it is a core raw material for the synthesis of antitumor drugs such as lometrexol and pyrimidine-based antibacterial compounds. Its derived heterocyclic structures can enhance the binding ability between drugs and targets.
In the synthesis of liquid crystal materials, it can react with nitrogen-containing compounds through condensation to prepare pyrimidine-based liquid crystals with specific photoelectric properties, improving the response speed and stability of display devices.
4. Convenience in Storage and Usage
Although sensitive to air and moisture, it can be stably stored by refrigeration and sealed packaging, without the need for special high-pressure or inert gas environments, thus reducing storage costs.
It is slightly soluble in common organic solvents (such as acetonitrile and DMSO), which can be adapted to most organic synthesis reaction systems and is easy to be compatible with other reagents.